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Do cystic fibrosis patients understand their drug therapy? J. Crawley, Regional Adult CF Unit, Liverpool, UK
Patients with CF need to take many different routine drug treatments, either as therapy for CF complications or to replace deficiencies associated with the condition. It is well known that compliance with complicated drug therapy is poor, and to investigate the reasons for this we audited the drug knowledge of a group of 24 consecutive CF patients admitted to our adult CF unit over a 1 month period. All were interviewed by the CF pharmacist who recorded the different medications taken and elucidated whether they understood the reasons for each therapy. In terms of replacement therapy, 23 (96%) were taking pancreatic enzymes and all knew the reasons for this. 22 (92%) were taking multivitamin capsules BPC and 13 of these (59%) did not know why. Also, 16 were taking vitamin E supplements and 10 of these (62%) did not know why. In terms of treatment for disease, of the 22 (92%) who took regular antistaphylococcal antibiotics, only 7 (32%) understood why. 9 (38%) were using dornase alfa, and all understood the reason for using it and when to use it in relation to physiotherapy. 16 (67%) were on regular short acting bronchodilator therapy (inhalers or nebulisers), and only 1 (6%) did not know the reason for such therapy. Conversely, 11 (46%) were using inhaled steroids, and only 3 (27%) of these knew what they were for and why they were taking them. Furthermore, of the 10 (42%) on regular oral steroids, only 7 (70%) knew what it was for. Thus, we have shown that frequently adult CF patients are not aware of the reasons for many of the therapies that they are taking, and this may in part explain why compliance is often poor. It may be of relevant that patients appeared to understand the need and use of rescue therapies (such as inhaled bronchodilators and pancreatic enzymes) rather than those with a prophylactic role (such as vitamin supplements). Our CF pharmacist has now embarked upon an active program of patient education into their routine drug treatment.
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